Forschungsgebiete
Main methods
We specialise in characterising protein-protein, protein-ligand and protein-cell interactions and furthermore engineer, produce and test novel immunmodulatory biopharmaceutical candidates. To achieve this we use a wide range of protein biochemical and immunological techniques ranging from recombinant protein technology (protein expression in bacterial, yeast and mammalian hosts followed by protein purification), knowledge-based protein engineering, protein chemistry, biophysical interaction analysis (e.g. SPR), fluorescent cell microscopy, fluorescence-activated cell sorting (FACS), protein and cell-based immunological assays (e.g. invovling patient-derived cells) and in collaboration structural biology techniques to obtain high resolution structures of porteins and protein complexes.