Publikationen
Weitere Informationen zu den Publikationen der AG Prof. Sippl finden sie hier:
2025
Schott A, Simon T, Müller S, Rausch A, Busch B, Glaß M, Misiak D, Dipto M, Elrewany H, Peters LM, Tripathee S, Ghazy E, Müller F, Rolnik RB, Lederer M, Hmedat A, Vetter M, Wallwiener M, Sippl W, Hüttelmaier S, Bley N. The IGF2BP1 oncogene is a druggable m(6)A-dependent enhancer of YAP1-driven gene expression in ovarian cancer. NAR Cancer. 2025 Feb 24;7(1):zcaf006. doi:10.1093/narcan/zcaf006.
H Nassar, AC Sarnow, I Celik, M Abdelsalam, D Robaa, W Sippl. Ternary Complex Modeling, Induced Fit Docking and Molecular Dynamics Simulations as a Successful Approach for the Design of VHL-mediated PROTACs Targeting the Kinase FLT3. ChemXriv, https://doi.org/10.26434/chemrxiv-2025-2n40d-v2
Adardour M, Mustafa AM, Ouba M, Lahcen MA, Seif EM, Ezzat MAF, Zaballos-García E, Mague JT, Hdoufane I, Cherqaoui D, Krämer OH, Sippl W, Ibrahim HS, Baouid A. Design, synthesis and molecular modeling of new Pyrazolyl-Benzimidazolone hybrids targeting breast Cancer. Bioorg Chem. 2025 Feb 15;157:108269. doi:10.1016/j.bioorg.2025.108269 .
Jungwirth J, Mieland AO, Piée-Staffa A, Heimburg T, Brenner W, Ehrhardt C, Sippl W, Henke A, Krämer OH. Pharmacologically induced proteolysis of histone deacetylase-6 attenuates influenza virus replication despite limited anti-tumor effects. Life Sci. 2025 Jan 13:123401. doi:10.1016/j.lfs.2025.123401.
Çelik C, İdiş ÖD, Özhan Y, Tirpanlar D, Unal N, Gungor B, Aru B, Gurdal EE, Sippl W, Sipahi H, Kırmızıbekmez H. Isolation of anti-inflammatory and cytotoxic secondary metabolites from Valeriana phu and evaluation of their mechanisms of action. Fitoterapia. 2025 Jan 6:181:106377. doi:10.1016/j.fitote.2025.106377 .
Waitman KB, Martin HJ, Carlos JAEG, Braga RC, Souza VAM, Melo-Filho CC, Hilscher S, Toledo MFZJ, Tavares MT, Costa-Lotufo LV, Machado-Neto JA, Schutkowski M, Sippl W, Kronenberger T, Alves VM, Parise-Filho R, Muratov EN.Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment. bioRxiv [Preprint]. 2024 Dec 5:2024.11.30.626092. doi:10.1101/2024.11.30.626092.
C. Vorreiter, D. Robaa, W. Sippl. Predicting Fragment Binding Modes Using Customized Lennard-Jones Potentials in Short Molecular Dynamics Simulations. Computational and Structural Biotechnology Journal, 27, 2025, 102-116 doi.org/10.1016/j.csbj.2024.12.017