Martin-Luther-Universität Halle-Wittenberg

Publikationen 2017

Weitere Informationen zu den Publikationen der AG Prof. Sippl finden sie hier:

M. Schiedel, D. Herp, S. Hammelmann, S. Swyter, A. Lehotzky, D Robaa, J. Oláh, J. Ovádi, W. Sippl,  M. Jung. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J. Med. Chem. 2017 Apr 17. doi:10.1021/acs.jmedchem.6b01872   . Commented in Science "In the Pipeline   ".

D. Wutz, D. Gluhacevic, A. Chakrabarti, K. Schmidtkunz, D. Robaa, F. Erdmann, C. Romier, W. Sippl, M. Jung, B. König. Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides. Org Biomol Chem. 2017 May 24. doi:10.1039/c7ob00976c.    [Epub ahead of print]

L. L. S. Scholte, M. M. Mourãa, F. Sviatopolk-Mirsky Paisa, J. Melesina, D. Robaa, A. C. Volpini, W. Sippl, R. J. Piercee, G. Oliveira, L. A. Nahum. Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases, Infect Genet Evol. 2017 May 13. pii: S1567-1348(17)30162-4. doi:10.1016/j.meegid.2017.05.011   . [Epub ahead of print]

T. Fischer, T. Krüger, A. Najjar, F. Totzke, C. Schächtele, W. Sippl, C. Ritter, A. Hilgeroth. Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors. Bioorg Med Chem Lett. 2017 Apr 19. pii: S0960-894X(17)30429-8. doi:10.1016/j.bmcl.2017.04.053.    [Epub ahead of print]

S. Vojacek, K. Beese, Z. Al Halabi, S. Swyter, A. Bodtke, C. Schulzke, M. Jung, W. Sippl, and A. Link. Three-Component Aminoalkylations Yielding Dihydronaphthoxazine-Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side-Chains. Arch Pharm (Weinheim). 2017 May 26. doi:10.1002/ardp.201700097   . [Epub ahead of print]

G. S. Hailu, D. Robaa, M. Forgione, M.W. Sippl, D. Rotili, A. Mai. Potential of Histone Deacetylase Inhibitors as Anti-Parasitic Agents. J. Med. Chem. 2017 Feb 27. doi:10.1021/acs.jmedchem.6b01595   .

E. E. Gurda,l B. Turgutalp, H. O. Gulcan, T. Erçetin, M. F. Sahin, I.  Durmaz. R. C.  Atalay, Q. D.  Nguyen, W. Sippl. M. Yarim. Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents. Anticancer Agents Med Chem. 2017 Apr 12. doi:10.2174/1871520617666170412153604.   

M. Schiedel, A. Fallarero, C. Luise, W. Sippl, P. Vuorela, and M. Jung. Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridinium salts as potent inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Med. Chem. Comm. 8, 465-470, 2017. DOI:10.1039/C6MD00647G   

C. Hempel, F. Totzke, C. Schaechtele, A. Najjar, W.  Sippl, C. Ritter, A. Hilgeroth. Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R. J. Enzyme Inhib. Med. Chem. 32, 271–276, 2017. doi:10.1080/14756366.2016.1247062   .

B. Sauer, T. S. Skinner-Adams, A. Bouchut, M. J. Chua, C. Pierrot, F. Erdmann, D. Robaa, M. Schmidt, J. Khalife, K. T. Andrews, W. Sippl Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum. Eur. J. Med. Chem. 127, 22-40, 2017. doi:10.1016/j.ejmech.2016.12.041.   

F. Erdmann, W. Lin, C. Platzer, M Schmidt, W. Sippl, G. Fischer, Y. Zhang. Augmented Reversible Photoswitching of Drug-Target Interaction through "Surface Borrowing". Biochem Pharmacol.125, 84-92, 2017. doi:10.1016/j.bcp.2016.11.011   

M. Schiedel, D. Robaa, T. Rumpf, W. Sippl, M. Jung. The Current State of NAD+-Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets. Med. Res. Rev. 2017 Jan 17. doi:10.1002/med.21436.   

D.Lehmann, L. Motlagh, D. Robaa, S. Zierz. Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features. Int. J. Mol. Sci.18, pii: E82, 2017. doi:10.3390/ijms18010082   

Zum Seitenanfang