Publikationen 1994 - 2002
2002
W. Sippl. Development of biologically active compounds by combining 3D QSAR and structure-based design. Journal of Computer-Aided Molecular Design 16, 825, 2002
W. Sippl. Computational approaches for the prediction of blood-brain barrier permeation. Current Medicinal Chemistry - Central Nervous System Agents 2, 211, 2002
W. Sippl. Binding affinity prediction of novel estrogen receptor ligands using receptor-based 3D QSAR methods. Bioor. Med. Chem. 10, 3741, 2002
2001
J.M. Contreras, I. Parrot, W. Sippl, Y.M. Rival and C.G. Wermuth. Design, Synthesis and Structure-Activity Relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as Acetylcholinesterase Inhibitors. J. Med. Chem. 44, 2707, 2001
W. Sippl, J.M. Contreras, I. Parrot, Y.M. Rival and C.G. Wermuth. Receptor-based 3-QSAR analyis of novel acetylcholinesterase inhibitors. Journal of Computer-Aided Molecular Design 15, 395, 2001
H. Stark, W. Sippl, X. Ligneau, J.M. Arrang, C. R. Ganellin, J.-C. Schwartz,
W. Schunack. Different Binding Properties of Human and Rat Histamine H3 Receptors. Bioor. Med. Chem. Lett. 11, 591, 2001
W. Sippl, J.M. Contreras, Y. Rival and C.G. Wermuth. Structure-based 3D QSAR and Design of Novel Acetylcholinesterase Inhibitors. In: H.-D. Höltje and W. Sippl (Eds.), Rational Approaches in Drug Design, Prous Science Press, Barcelona, 89-97, 2001
W. Sippl. Development of Nonlinear Models for Prediction of Biopharmaceutical Properties. Arch. Pharm. Pharm. Med. Chem. 334, S 2, 14, 2001
H.-D. Höltje and W. Sippl. Rational Approaches to Drug Design. Prous Science Press, Barcelona, 2001
2000
W. Sippl and H.-D. Höltje. Structure-based 3D-QSAR-merging the accuracy of structure-based alignments with the computational efficiency of ligand-based methods. Journal of Molecular Structure: Theochem, 503, 31-50, 2000.
W. Sippl. Receptor-based 3D QSAR analysis of estrogen receptor ligands – merging the accuracy of receptor-based alignments with the computational efficiency of ligand-based methods. Journal of Computer-Aided Molecular Design 14, 559-572, 2000.
W. Sippl, J.M. Contreras, Y. Rival and C.G. Wermuth. Comparative Molecular Field Analysis of Aminopyridazine Acetylcholinesterase Inhibitors. In: K. Gundertofte, F.S: Jorgensen (Ed.), Molecular Modelling and Predicting of Bioactivity, Plenum Press, New York, 53-58, 2000.
1999
A. Gysler, B. Kleuser, W. Sippl, K. Lange, H.C. Korting, H.-D. Höltje, M. Schäfer-Korting. Differential Skin Penetration and Metabolism of Topical Glucocorticoids contributes to the Increased Benefit/Risk Ratio of Prednicarbate. Pharm. Res. 16, 1386-91, 1999
1998
W. Sippl, H. Stark and H.-D. Höltje. Development of a Binding Site Model for Histamine H3-Receptor Agonists. Pharmazie 53, 433-437, 1998
1997
H.-D. Höltje and W. Sippl. Molecular Modelling Studies on Histamine H2- and H3-Receptor Agonists. Proceedings of the XIV Symposium on Medicinal Chemistry, Maastricht, Netherlands. Elsevier Science Publ. Amsterdam, 137-145, 1997
1995
W. Sippl, H. Stark and H.-D. Höltje. Computer-Assisted Analysis of Histamine H2- and H3-Receptor Agonists. Quant. Struct-Act. Relat. 14, 121-125, 1995
1994
W. Sippl and H.-D. Höltje. Sterical and Electronical Properties of Histamine H2-Receptor Agonists. European Journal of Pharmaceutical Sciences 2, 139, 1994