Publications 2019
C.V. Simoben, F. Ntie-Kang, W. Sippl. Case studies on computer-based identification of natural products as lead molecules. Physical sciences reviews - Berlin: de Gruyter, Bd. 4.2019, 9.
Z. Kutil, J. Mikešová, M. Zessin, M. Meleshin, Z. Nováková, G. Alquicer, A. Kozikowski, W. Sippl, C. Bařinka, M. Schutkowski. Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors. ACS Omega 4, 22, 19895-19904, 2019. doi:10.1021/acsomega.9b02808
M. Zessin, Z. Kutil, M. Meleshin, Z. Nováková, E. Ghazy, D. Kalbas, M. Marek, C. Romier, W. Sippl, C. Bařinka, M. Schutkowski. One-Atom-Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity. Biochemistry. 58(48):4777-4789, 2019. doi:10.1021/acs.biochem.9b00786 .
A. Najjar, A. Olğaç, F. Ntie-Kang, W. Sippl. Fragment-based drug design of nature-inspired compounds. Physical sciences reviews - Berlin: de Gruyter, Bd. 4.2019, 9. doi:10.1515/psr-2018-0110
L. Temme, F. Börgel, D. Schepmann, D. Robaa, W. Sippl, C. Daniliuc, B. Wünsch. Impact of hydroxy moieties at the benzo[7]annulene ring system on GluN2B affinity: Design, in silico docking, synthesis and biological evaluation. Bioorg Med Chem. 27(23):115146, 2019. doi:10.1016/j.bmc.2019.115146 .
M. Roatsch, I. Hoffmann, M. Abboud, R. Hancock, H. Tarhonskaya, K.F. Hsu, S. Wilkins, T.L. Yeh, K. Lippl, K. Serrer, I. Moneke, T. Ahrens, D. Robaa, S. Wenzler, H. Franz, W. Sippl, S. Lassmann, S. Deiderichs, E. Schleicher, C. Schofield, A.Kawamura, R. Schüle, M Jung.The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases. ACS Chem Biol. 14(8):1737-1750, 2019. doi:10.1021/acschembio.9b00289
N. Miekus, C. Luise, W. Sippl, T. Baczek, C. E.H. Schmelzer, A. Heinz
MMP-14 degrades tropoelastin and elastin. Biochimie.165:32-39, 2019. doi:10.1016/j.biochi.2019.07.001
D. Kalinin, O. Agoglitta, H. Van de Vyver, J. Melesina, S.Wagner, B. Riemann, M. Schäfers, W. Sippl, B. Löffler, and R. Holl. Proline-based Hydroxamates Targeting the Zinc-Dependent Deacetylase LpxC: Synthesis, Antibacterial Properties, and Docking Studies. Bioorg Med Chem. 27, 997-2018, 2019. doi:10.1016/j.bmc.2019.03.056
A. Dreger, O. K. O. Agoglitta, E. F. Bülbül J. Melesina, W. Sippl,and R. Holl. Chiral pool synthesis, biological evaluation and molecular docking studies of C-furanosidic LpxC inhibitors. ChemMedChem. 14, 871-886, 2019. doi:10.1002/cmdc.201900068
K. Vögerl, N. Ong, J. Senger, D. Herp, K. Schmidkunz, M. Marek, M. Müller M, K. Bartel, T. Shaik, N. Porter, D. Robaa, D. Christianson, C. Romier, W. Sippl, M. Jung, F Bracher. Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 (HDAC6) Inhibitors. J Med Chem. 62, 1138–1166, 2019. doi:10.1021/acs.jmedchem.8b01090 .
A. Haider, A. Müller Herde, S. D. Krämer, J. Varisco, C. Keller, K. Frauenknech, Y. P. Auberson, L. Temme, D. Robaa, W. Sippl, R. Schibli, B. Wünsch, L. Mu, S. M. Ametamey. Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and Tightrope Walk between GluN2B- and Sigma1 Receptor-Targeted PET Imaging. J Nucl Med. 60(8):1167-1173, 2019. doi:10.2967/jnumed.118.221051
A, Najjar, C. Platzer, A. Luft, C. Assmann, N. H. Aly El Ghazawy, F. Erdmann, W. Sippl, M. Schmidt. Computer-aided design, synthesis and biological characterization of novel inhibitors for PKMYT1. Eur. J.Med. Chem. 161, 479-492, 2019. DOI:10.1016/j.ejmech.2018.10.050