Martin Luther University Halle-Wittenberg

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M.Sc. Fady Baselious

Tel. ++49 345 55 25194
e-mail: f_noshy(at)

Molecular design of novel HDAC inhibitors and PROTACs


F. Baselious, S. Hilscher, S. Hagemann, S. Tripathee, D. Robaa, C. Barinka, S. Hüttelmaier, M. Schutkowski, W. Sippl. Utilization of an Optimized AlphaFold Protein Model for Structure-Based Design of a Selective HDAC11 Inhibitor with Anti-neuroblastoma Activity. 10.26434/chemrxiv-2024-6f790    

F. Baselious, S. Hilscher, D. Robaa, C. Barinka, M. Schutkowski, W. Sippl. Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor. Int. J. Mol. Sci. 2024, 25(2), 1358;    

F. Baselious, D. Robaa, W. Sippl. Utilization of AlphaFold Models for Drug Discovery: Feasibility and Challenges. Histone Deacetylase 11 as a Case Study. Comput Biol Med. 167:107700, 2023. doi:10.1016/j.compbiomed.2023.107700    

Opitz A, Seitz LM, Krystof V, Baselious F, Holzer M, Sippl W, Hilgeroth A. Novel effective small-molecule inhibitors of protein kinases related to tau pathology in Alzheimer's disease. Future Med Chem. 2022 Aug;14(16):1175-1186. doi: 10.4155/fmc-2022-0061. Epub 2022 Aug 3.

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