Talha Zahid Yesiloglu
Talha Zahid Yesiloglu
M.Sc. Talha Zahid Yesiloglu
Tel. ++49 345 55 25194
e-mail: talhazahidyesiloglu(at)windowslive.com
Computer based analysis of histone deacetylase 10 inhibitors
Histone deacetylases are important modulators of epigenetic gene regulation and the activity of non-histone protein substrates. While for HDACs 1-3 and 6 many potent selective inhibitors have been obtained, for other subtypes much less is known on selective inhibitors and the consequences of their inhibition. In previous work, we have identified HDACs 8 and 10 as promising anticancer targets and respective inhibitors as candidates for further optimization. Crystal structures of HDAC8 and homologues in complex with inhibitors as well as homology models of HDAC10 will be used for structure- and computer-based optimization of the lead structures.