Matthes Zessin
M.Sc. Matthes Zessin
Tel. ++49 345 55 24887
e-mail: matthes.zessin(at)googlemail.com
Research topic
Development and application of novel bioassays for histone deacetylases
Publications/poster
M. Zessin, M. Meleshin, L. Praetorius, W. Sippl, C. Bařinka, M. SchutkowskiUncovering robust delactoylase and depyruvoylase activities of HDAC isoformsACS Chem Biol. 2022 May 31. doi:10.1021/acschembio.1c00863
D. Kalbas, M. Meleshin, S. Liebscher, M. Zessin, E.F. Bulbul, J. Melesina, C. Schiene-Fischer, F. Bordusa, W. Sippl, M. Schutkowski. Small changes make the difference for SIRT2: Two different binding modes for 3-arylmercapto-acylated lysine derivatives. Biochemistry, 2022 Aug 16. doi:10.1021/acs.biochem.2c00211
E. F. Bülbül, J. Melesina, H. S. Ibrahim, M. Abdelsalam, A. Vecchio, D. Robaa, M. Zessin, M. Schutkowski, and W. Sippl.Docking, Binding Free Energy Calculations and in vitro Characterization of Pyrazine Linked 2-Aminobenzamides as new Class I Histone Deacetylase (HDAC) Inhibitors.Molecules. 2022 Apr 14;27(8):2526. doi:10.3390/molecules27082526
N. Cheshmazar, S.Hemmati, M. Hamzeh-Mivehroud, B. Sokouti, M. Zessin, M. Schutkowski, W. Sippl, H. Nozad Charoudeh, S. Dastmalchi.Development of new inhibitors of HDAC 1-3 enzymes aided by in silico design strategies.J Chem Inf Model. 2022 Apr 25. doi:10.1021/acs.jcim.1c01557
H. Ibrahim, M. Abdelsalam, Y. Zeyn, M. Zessin, E F. Bülbül, A. M. Mustafa, M. A. Fischer, P. Zeyen, A. Vecchio, P. Sun, F. Erdmann, M. Schmidt, D. Robaa, C. Romier, M. Schutkowski, O. H. Krämer, and W. Sippl.Synthesis and structure-activity relationship studies of pyrazine linked 2-aminobenzamides as new class I selective histone deacetylase (HDAC) inhibitors and their biological characterization in leukemic cellsInt.J. Mol. Sci. 23(1), 369, 2022. https://doi.org/10.3390/ijms23010369
Z. Kutil, J. Mikešová, M. Zessin, M. Meleshin, Z. Nováková, G. Alquicer, A. Kozikowski, W. Sippl, C. Bařinka, M. Schutkowski. Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors. ACS Omega 4, 22, 19895-19904, 2019. doi:10.1021/acsomega.9b02808
M. Zessin, Z. Kutil, M. Meleshin, Z. Nováková, E. Ghazy, D. Kalbas, M. Marek, C. Romier, W. Sippl, C. Bařinka, M. Schutkowski. One-Atom-Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity. Biochemistry. 58(48):4777-4789, 2019. doi:10.1021/acs.biochem.9b00786 .