Martin Luther University Halle-Wittenberg

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Publikationen 2015

G. Wolber, W. Sippl Pharmacophore Identification and Pseudo-Receptor Modeling In  the Practice of Medicinal Chemistry, 4th edition, Edited by:Camille  Georges Wermuth, David Aldous, Pierre Raboisson and Didier Rognan,  Elsevier, 2015

A.-T. Hauser, M. Roatsch, J. Schulz-Fincke, D. Robaa, W. Sippl, M.  Jung. Discovery of Histone Demethylase Inhibitors. In: Epigenetic  Technological Applications (Ed.: Y. G. Zheng) 397-424, 2015

W. Lei, M. Kofler, G. Brosch, J. Melesina, W. Sippl, E. D Martinez, J. Easmon.2-Benzazolyl-4-piperazin-1-ylsulfonylbenzenecarbohydroxamic  acids as novel selective histone deacetylase-6 inhibitors with  antiproliferative activity. PlosOne, 2015 Dec 23;10(12):e0134556. doi: 10.1371/journal.pone.0134556    . eCollection 2015

S. Gawaskar, D. Schepmann, A. Bonifazi, D. Robaa, W. Sippl, B. Wünsch.Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: surprising effect of a nitro group in 2-position. Bioorg Med Chem Lett. 25, 5748-51, 2015. doi:10.1016/j.bmcl.2015.10.076.    

J. Melesina, C. Romier, R. Pierce, W. Sippl. Homology Modeling of Parasite Histone Deacetylases to Guide the Structure-Based Design of Selective Inhibitors. J. Mol. Graph. Mod. 62, 342-361, 2015. doi:10.1016/j.jmgm.2015.10.006.    

M. Oelze, K.A. Mahmoud, W. Sippl, T. Wersig, A. Hilgeroth, C. A. Ritter. Novel  4-anilino-α-carboline derivatives induce cell death in nonadhesive  breast cancer cells through inhibition of Brk activity. Int J Clin Pharmacol Ther. 53, 1052-5, 2015. doi:10.5414/CPXCES14EA07.    

B. Tewes, B. Frehland, D. Schepmann, D. Robaa, T. Uengwetwanit, F. Gaube, T. Winckler, W. Sippl, B. Wünsch. Enantiomerically pure 2-methyltetrahydro-3-benzazepin-1-ols as GluN2B-selective NMDA receptor antagonists. J Med Chem 58, 6293-305. DOI:10.1021/acs.jmedchem.5b00897    

K. Rüben, A. Wurzlbauer, A. Walte, W. Sippl, F. Bracher, W. Becker. Selectivity profiling and biological activity of novel beta-carbolines as potent and selective DYRK1 kinase inhibitors. PlosOne10, e0132453, 2015. doi:10.1371/journal.pone.0132453    

S. B. Babiaka, F. Ntie-Kang, B. Ndingkokhar, J. A. Mbah, W. Sippl,c and J. N. Yong. The chemistry and bioactivity of Southern African flora II: Flavonoids, quinones and minor compound classes. RSC Adv. 5, 57704-57720, 2015. DOI:10.1039/C5RA05524E   

A. Rohe, C. Platzer, A. Masch, S. Greiner, C. Henze, C. Ihling, F. Erdmann, M. Schutkowski, W. Sippl, M. Schmidt. Identification of peptidic substrates for the human kinase Myt1 using peptide microarrays. Bioorg. Med. Chem. 23, 4936-42, 2015. doi:10.1016/j.bmc.2015.05.021    

A. Chakrabarti, I. Oehme, O. Witt, G. Oliveira, W. Sippl , C. Romier, R. J. Pierce, M. Jung. HDAC8, a multifaceted target 1 for therapeutic interventions.Trend Pharmacol, Sci. 36, 481-92, 2015. doi:10.1016/    

M. Marek, G. Oliveira, R. J. Pierce, W. Sippl, M. Jung, and C. Romier.Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives. Future Med Chem 7, 783-800, 2015. doi:10.4155/fmc.15.25    

J. Lancelot, A. Cabezas-Cruz, S. Caby, M. Marek, J. Schultz, C. Romier, W. Sippl, M. Jung, R. J. Pierce. Schistosome sirtuins as drug targets. Future Med Chem. 7, 765-82, 2015, doi:10.4155/fmc.15.24    

B. Karaman, W. Sippl. Docking and binding free energy calculations of sirtuin inhibitors. Eur. J. Med. Chem. 93, 584-98. 2015   DOI:10.1016/j.ejmech.2015.02.045    

JM Gajer, SD Furdas, A Gründer, M Gothwal, U Heinicke, K Keller, F Colland, S Fulda, HL Pahl, I Fichtner, W Sippl and M Jung. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis 4, e137, 2015. doi:10.1038/oncsis.2014.51    

T. Rumpf, M. Schiedel, B. Karaman, C. Rössler, B. J. North, K. I.  Ladwein, M. Gajer, C. Steegborn, D. A. Sinclair, M. Schutkowski,, W.  Sippl, O. Einsle, M. Jung. Selective Sirt2 inhibition by ligand induced rearrangement of the active site. Nat. Comm. 6, 6263, 2015 doi:10.1038/ncomms7263    

T. Uengwetwanit, D. Robaa, W. Sippl. Analysis of the Resistance of Hepatitis C virus NS5B polymerase inhibitors via Docking and Molecular Dynamics Simulation. Mol. Inf. 34, 78-83, 2015, doi:10.1002/minf.201400048