Martin Luther University Halle-Wittenberg

Reagenzgläser auf einem Tablett

Further settings

Login for editors

Publications 2008

J. Jyrkkärinne, B. Windshügel, T. Rönkkö, A. Tervo, J. Küblbeck, M. Lahtela-Kakkonen, W. Sippl, A. Poso and P. Honkakoski. Insights into Ligand-Elicited Activation of Human Costitutive Androstane Receptor Based on Novel Agonists and Three-Dimensional Quantitative Structure-Activity Relationship. J. Med. Chem. 2008, 51, 7181-7192

U. Uciechowska, J. Schemies, R. Neugebauer, E. Huda, M. Schmitt, R. Meier, E. Verdin, M. Jung, W. Sippl. Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free Energy Calculations and Biological Testing. Chem.Med.Chem., 2008, 3, 1965-1976

J. Küblbeck, J. Jyrkkärinne, A. Poso, M. Turpeinen, W. Sippl, P. Honkakoski, B. Windshügel. Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor. Biochem. Pharmacol. 76, 1288-97, 2008

R. C. Neugebauer, W. Sippl and M. Jung. Inhibitors of NAD+ dependent histone deacetylases (sirtuins). Current Pharmaceutical Design 14, 562-73, 2008

J. Wollmann, C. Baumert, G. Erlenkamp, W. Sippl and A. Hilgeroth. Novel Insight in Inhibitor Binding of Highly Symmetric HIV-1 Protease. ChemBioChem 9, 874-78, 2008

R. C. Neugebauer, U. Uciechowska, R. Meier, H. Hruby, V. Valkov, E. Verdin, W. Sippl and M. Jung. Structure activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J. Med. Chem., 51, 1203-13, 2008

S. Schäfer, L. Saunders, E. Eliseeva, A. Velena, M. Jung, A. Schwienhorst, A. Dickmanns, R. Ficner, S. Schlimme, W. Sippl, E. Verdin and M. Jung. Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg. Med. Chem., 16, 2011-33, 2008

H.-D. Höltje, W. Sippl, D. Rognan, G. Folkers. Molecular Modelling - Basic Principles and Applications, 3nd revised edition. VCH Publisher, Inc., New York 2008

J.M. Contreras and W. Sippl. Identical and Non-identical Twin Drugs
In the Practice of Medicinal Chemistry, 3rd edition, Ed. Camille G. Wermuth, Academice Press, London, UK, 2008

W. Sippl. Pharmacophore Concepts, Pseudoreceptors and Receptor Mapping
In the Practice of Medicinal Chemistry, 3rd edition, Ed. Camille G. Wermuth, Academice Press, London, UK, 2008