Martin Luther University Halle-Wittenberg

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Publications 2012

B. Maurer, T. Rumpf,  M. Scharfe, J. Schemies, M. L. Schmitt,  D. Stolfa,  W. He, E. Verdin, W. Sippl, and M. Jung. Inhibitors of the NAD dependent protein desuccinylase and demalonylase Sirt5. ACS Med. Chemistry Letters 3, 1050-1053, 2012. doi:10.1021/ml3002709   

V.Tell, K. A. Mahmoud, K. Wichapong, C. Schächtele, F. Totzke, W. Sippl and Andreas Hilgeroth. Novel aspects in structure-activity relationships of profiled 1-aza-9-oxafluorenes as inhibitors of alzheimer disease-relevant kinases cdk1, cdk5 and gsk3β. Med. Chem. Comm. 3, 1413-1418, 2012. doi:10.1039/C2MD20201H   

I. Hoffmann, M. Roatsch, M. L. Schmitt, L. Carlino, M. Pippel, W. Sippl, M. Jung. The role of histone demethylases in cancer therapy. Mol. Oncol. 6, 683-703, 2012. doi:10.1016/j.molonc.2012.07.004   

D. A. Stolfa, O. Einsle, W. Sippl, and M. Jung. Current trends in epigenetic drug discovery. Future Med. Chem. 4, 2029-37, 2012. doi:10.4155/fmc.12.144   

J. Köhler, G. Erlenkamp, A. Eberlin, T. Rumpf, I. Slynko, E. Metzger, R. Schüle, W. Sippl, and M. Jung. Lestaurtinib Inhibits Histone Phosphorylation and Androgendependent Gene Expression in Prostate Cancer Cells. PlosOne 7, e34973, 2012. doi:10.1371/journal.pone.0034973   

C Reverdy, S Conrath, R Lopez, C Planquette, C Atmanene, V Collura, J Harpon, V Battaglia, V Vivat, W Sippl and F Colland. Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme. Chem. Biol. 19, 467-77, 2012. doi:10.1016/j.chembiol.2012.02.007   

H. Abromeit, S. Kannan, W. Sippl, G. Scriba. A new non-peptide substrate of human sirtuin in a capillary electrophoresis based assay. Investigation of the binding mode by docking experiments. Electrophoresis 33, 1652-9, 2012. doi:10.1002/elps.201100641   

S.D. Furdas, S. Kannan, W. Sippl, M. Jung. Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates. Arch. Pharm. 345, 7-21, 2012. doi: 10.1002/ardp.201100209

S.D. Furdas, S. Shekfeh, S. Kannan, W. Sippl, M. Jung. Rhodanine carboxylic acids as novel inhibitors of histone acetyltransferases. Med. Chem. Comm. 3, 305-311, 2012. doi:10.1039/C2MD00211F   

S. Furdas, L. Carlino, W. Sippl, M. Jung. Inhibition of bromodomain-mediated protein-protein interactions as a novel therapeutic strategy. Med. Chem. Comm. 3, 123-134, 2012. doi:10.1039/C1MD00201E    

A Rohe; F Erdmann; Cl Baeßler; K Wichapong; W Sippl; M Schmidt. In vitro and in silico studies on substrate recognition and acceptance of human PKMYT1, a Cdk1 inhibitory kinase. Bioorganic & Medicinal Chemistry Letters 22, 1219-1223, 2012. doi:10.1016/j.bmcl.2011.11.064   

U. Uciechowska, J. Schemies, M. Scharfe, M. Lawson, K. Wichapong, M. Jung, W. Sippl. Binding  free energy calculations and biological testing of  novel  thiobarbiturates as inhibitors of the human NAD+ dependent  histone  deacetylase Sirt2. Med. Chem. Comm. 3, 167- 173, 2012. doi:10.1039/C1MD00214G