Publications 2010
Schemies J, Uciechowska U, Sippl W, Jung M. NAD(+) -dependent histone deacetylases (sirtuins) as novel therapeutic targets. Med Res Rev. 30, 861-89. 2010. DOI:10.1002/med.20178
Krug M, Erlenkamp G, Sippl W, Schächtele C, Totzke F, Hilgeroth A. Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 20, 6915-9, 2010. DOI:10.1016/j.bmcl.2010.10.004
Wichapong K, Lawson M, Pianwanit S, Kokpol S, Sippl W. Postprocessing of protein-ligand docking poses using linear response MM-PB/SA: application to Wee1 kinase inhibitors. J Chem Inf Model. 50, 1574-88, 2010. DOI:10.1021/ci1002153
Lawson M, Uciechowska U, Schemies J, Rumpf T, Jung M, Sippl W. Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins). Biochim Biophys Acta. 1799, 726-39, 2010. DOI:10.1016/j.bbagrm.2010.06.003
E.-M. Bissinger, R. Heinke, W. Sippl, M. Jung Targeting epigenetic modifiers: Inhibitors of histone methyltransferases. MedChemComm 1(2), 114-124, 2010. DOI:10.1039/c0md00062k
Heinke R., Sippl W. Entwicklung von Histon-Desacetylaseinhibitoren. Potente Wirkstoffe vor allem bei Krebserkrankungen. Pharmazie in Unserer Zeit, 39, 183-189, 2010. DOI:10.1002/pauz.201000364
Vogel M., Lawson M., Sippl W., Conrad U., Roos W. Sanguinarine reductase - structure and mechanism of an enzyme of alkaloid detoxication. J.Biol.Chem. 285, 18397-406, 2010. DOI:10.1074/jbc.M109.088989
M. Lindner, W. Sippl, A. A. Radwan. Pharmacophore Elucidation and Molecular Docking Studies on 5-Phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic Acid Derivatives as COX-2 Inhibitors. Sci Pharm. 78, 195-214, 2010. DOI:10.3797/scipharm.0912-19
A. Heinz, M. Jung, D. Laurent, W. Sippl, S. Taddese, C. Ihling, A. Rusciani, J.Günther, A. Weiss, R. Neubert, C. Schmelzer. Degradation of tropoelastin by matrix metalloproteinases: cleavage site specificities and release of matrikines FEBS J., 277, 1939-1956, 2010. DOI:10.1111/j.1742-4658.2010.07616.x
R. Meier, M. Pippel, F. Brandt, W. Sippl, C. Baldauf. ParaDockS – A molecular framework for molecular docking with population-based metaheuristics J Chem Inf Model. 50, 879-89, 2010. DOI:10.1021/ci900467x
K. Huber, J. Schemies, U. Uciechowska, J. M. Wagner, T. Rumpf, F. Lewrick, R. Süss, W. Sippl, M. Jung and F. Bracher. Novel 3‑Arylidene-indolin-2‑ones as inhibitors of NAD+-dependent histone deacetylases (sirtuins). J. Med. Chem. 53, 1383-86, 2010. DOI:10.1021/jm901055u
K. Wichapong, S. Pianwanit, W. Sippl, S. Kokpol. Homology Modeling and Molecular Dynamics Simulations of Dengue Virus NS2B/NS3 Protease: Insight into Molecular Interaction. J. Mol. Rec. 23, 283-300, 2010. DOI:10.1002/jmr.977